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MTHFR and methylfolate

Depression, Anxiety, Autism, Autoimmune Disorders, Fatigue, Headaches, elevated homocysteine levels, Fibromyalgia, IrritableBowelSyndrome, Parkinson’s, stroke, Heart Disease, multiple miscarriages, and birth defects…What do they have in common? A common genetic mutation called MTHFR.

What is MTHFR? MTHFR has been talked about a lot recently, but what is it? It is a small gene mutation. MTHFR stands for the methylenetetrahydrofolate reductase. The name is not important, but the function is, because the MTHFR genes codes for an essential enzyme in methylation.

What is methylation?

To understand methylation, you must first understand what a methyl group is, and why it is important. It’s really a very simple molecule. It’s one carbon hanging out with 3 hydrogens.

Your body passes this methyl group from one chemical to another in your body in a process called methylation. These chemicals are things like enzymes and DNA. For simplicity sake, I will call them all enzymes.

It’s like in this video with children passing balloons around a circle. The balloons are methyl groups. This is really critical since methylation is needed for 240 different enzyme reactions in the body. Methylation is vital to Feeling Good in Your Genes

You need methylation for some very important functions in your body:

Methylation is needed to removing many chemicals and toxins from your body. Remember last time you forgot to take out the trash??? Smelly! If you don’t get rid of some toxins and chemical, it’s pretty rotten, too.

Methylation is crucial for Metabolizing hormones and keeping them in balance.

Methylation is needed for Making and breaking down chemical messengers in the brain, like serotonin and dopamine

Good methylation helps you build up your defenses…it is need to build some immune cells

Methylation is also important in helping you produce energy!

Perhaps the most important function is in the duplication and “reading” of DNA. In fact, just stopping the methylation of DNA in mice triggers the autoimmune disease Lupus. Did you catch that? Stopping methylation of DNA can trigger Lupus in mice! These are all really good reasons to keep the balloons going around the circle.

MTHFR gene mutations cause poor methylation. How common is MTHFR? Studies show that at least 40% of the U.S. population has at least one MTHFR mutation. There are 4 significant mutations studied so far.

How do I find out if I have a mutation? You can request a blood test from your regular practitioner. A better option is to do a simple saliva test through It takes a little longer to get your results, but you also get 1000’s of other genes, also. Here is a link to the website:

After I get my 23andme results back, what do I do? Contact me. I will help you download the raw data and for $40 we can get back a complete genetic report showing us which methylation genes we can support to change how you Feel in Your Genes.

What can I do if I have an MTHFR mutation? For someone that has the MTHFR mutation, it is helpful to take methylfolate. However, methylfolate should be taken with caution and under the direction of a practitioner trained in its use (I have this training and would love to assist you). Methylfolate, at any point in therapy, can cause irritability, insomnia, sore muscles, rash, achy joints, severe anxiety, palpitations, nausea, headaches, and migraines. I would love to help you treat your MTHFR mutation AND improve your methylation. For more information about dosing, contact me.

Other nutrients may also be needed to optimize therapy. I recommend Foundation Multi as a foundation to feeling better. It contains no folic acid, only methylfolate. For more information, you can watch the video below or purchase it via the button below.

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